The purpose of this research work was to improve the solubility and dissolution rate of the telmisartan by using water soluble polymers like Hydroxypropyl methyl cellulose (HPMC E5 LV), Polyethylene glycol-4000 (PEG 4000) and Polyvinyl pyrrolidone (PVP K 30) at pH 7.5 (FDA recommended) using Solid dispersion technique. Solid dispersion of telmisartan were prepared using HPMC E5 LV, PEG 4000 and PVP K 30 polymers in ratios 1:1 to 1:4 (Drug :polymer). Saturation solubility, in-vitro dissolution, particle size distribution, FT-IR spectroscopy, PXRD, DSC and SEM studies were carried out. The results indicated that the formulation containing 1:4 ratio of drug: PVP-K30 showed the cumulative release of 98.42 % as compared to 9.36 % for the pure drug in pH 7.5 phosphate buffers and more than 100 times increases in solubility. X-ray diffraction, differential scanning calorimetry and Fourier transform infrared characterization indicated the solid dispersions exhibited change in crystalline nature. Solid dispersion of telmisartan has been successfully formulated avoiding the need for surfactant, basic amino acid, solubilising agents like alkali hydroxide uses during formulation, there by simplifying the techniques. It was concluded that PVP K 30 can be very well utilized as a carrier to improve the solubility and dissolution rate of poorly soluble drug telmisartan.
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